Clinical observations from several large-scale DES registries have revealed the occurrence of late adverse events that questions the safety of DES. However, the caging of the vessel permanently with a metallic implant runs the risk of impairing endothelial function and decreasing positive lumen remodeling. Similar content being viewed by othersĬurrent metallic drug-eluting stents (DES) have thin struts with biocompatible polymer coating, making them the first choice device for the treatment of coronary artery disease. In conclusion, BaSO 4/PLLA-based nanocomposites could potentially be used as materials for BRS with improved mechanical and radiopaque properties. Finite element analysis (FEA) showed that scaffold fabricated from the novel nanocomposite material has improved scaffolding ability, specifically that the strut thickness could be decreased compared to the conventional PLLA scaffold. Enhancement in mechanical properties is attributed to functionalization which decreased the agglomeration of the nanofillers and improved dispersion. Rigid nanofillers improved the tensile modulus and strength of PLLA (60% and 110% respectively), while the use of SA-BaSO 4 caused a significant increase (~110%) in the elongation at break. Stearic-acid (SA) modified BaSO 4 nanofillers were used to examine the effect of functionalization. To this end, polymer-matrix composites consisting of PLLA reinforced with 5–20 wt% barium sulfate (BaSO 4) nanofillers as a potential BRS material was evaluated. We hypothesized that nanofillers can be used to enhance the mechanical properties considerably in PLLA. However, such polymers have weaker mechanical properties as compared to metals, limiting their use in BRS. Bioresorbable scaffolds (BRS) were introduced to overcome limitations of current metallic drug-eluting stents and poly-L-lactide (PLLA) has been used in the fabrication of BRS due to its biodegradability and biocompatibility.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |